Sequence Browser (Q13535-3)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
2644

Isoforms (From UniProt)

Isoform
Remark
Ref
Q13535-1
Q13535-3  
No experimental confirmation available.
VSP_036907 VSP_036908
Q13535-2
VSP_013305 VSP_013304
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3D Structure Viewer - JSMol  

3D Structure Display

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Protein Information (From UniProt)

Protein:
Serine/threonine-protein kinase ATR
Other Names:
Ataxia telangiectasia and Rad3-related protein, FRAP-related protein 1
Primary Accession:
Q13535
Other Accessions:
Q59HB2, Q7KYL3, Q93051, Q9BXK4
Gene :
ATR*, synonyms (FRP1)
Organism :
Human
Entry Name :
ATR_HUMAN
Length :
2,644
Mass (Da) :
301,367
Last modified :
05-Jan-2004
Version :
v3
Isoforms :
3 
Structures :
Experimental 0 | Phyre prediction 0
Function : Show Hide

Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.