Sequence Browser (Q5T6X5-1)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
926

Isoforms (From UniProt)

Isoform
Remark
Ref
Q5T6X5-1  
Major isoform.
Q5T6X5-2
VSP_016454
Q5T6X5-3
VSP_016455
Click on Isoform of interest to be redirected to the corresponding page

Variants (From UniProt)

Type
Variation
Position
splice variant
Missing
446 - 516
sequence variant
I → R
144
mutagenesis site
S → A
149
splice variant
Missing
271 - 445
sequence variant
P → S
91
sequence variant
I → T
599
mutagenesis site
T → A
172

3D Structure Viewer - JSMol  

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Protein Information (From UniProt)

Protein:
G-protein coupled receptor family C group 6 member A
Other Names:
G-protein coupled receptor GPCR33
Primary Accession:
Q5T6X5
Other Accessions:
Q6JK43, Q6JK44, Q8NGU8, Q8NHZ9, Q8TDT6
Gene :
GPRC6A*
Organism :
Human
Entry Name :
GPC6A_HUMAN
Length :
926
Mass (Da) :
104,753
Last modified :
21-Jan-2004
Version :
v1
Isoforms :
3 
Variants :
7 
Interactions :
0 
Structures :
Experimental 0 | Phyre prediction 2
Function : Show Hide

Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+). Activated by extracellular calcium and osteocalcin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalent ions and its responsiveness to anabolic steroids.

Interactions (From UniProt)

No interactions reported for this protein.