Sequence Browser (Q5T6X5-3)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
926

Isoforms (From UniProt)

Isoform
Remark
Ref
Q5T6X5-1
Major isoform.
Q5T6X5-2
VSP_016454
Q5T6X5-3  
VSP_016455
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3D Structure Viewer - JSMol  

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Protein Information (From UniProt)

Protein:
G-protein coupled receptor family C group 6 member A
Other Names:
G-protein coupled receptor GPCR33
Primary Accession:
Q5T6X5
Other Accessions:
Q6JK43, Q6JK44, Q8NGU8, Q8NHZ9, Q8TDT6
Gene :
GPRC6A*
Organism :
Human
Entry Name :
GPC6A_HUMAN
Length :
926
Mass (Da) :
104,753
Last modified :
21-Jan-2004
Version :
v1
Isoforms :
3 
Structures :
Experimental 0 | Phyre prediction 3
Function : Show Hide

Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+). Activated by extracellular calcium and osteocalcin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalent ions and its responsiveness to anabolic steroids.