Sequence Browser (Q86UL8-1)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
1455

Isoforms (From UniProt)

Isoform
Remark
Ref
Q86UL8-1  
Q86UL8-2
VSP_008435
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Variants (From UniProt)

Type
Variation
Position
splice variant
QQVPPRTSFRMDSSG → R
757 - 771
sequence conflict
G → C
1250
sequence conflict
P → L
1383
sequence conflict
E → A
1401
sequence conflict
PG → SV
1414 - 1415
sequence conflict
P → A
1423
sequence conflict
V → G
1429
sequence conflict
E → Q
1234
sequence conflict
E → K
1291
sequence conflict
FAGPGG → SADPAD
1389 - 1394
sequence conflict
G → A
1411
sequence conflict
G → A
1420
sequence conflict
K → R
1426
sequence conflict
P → R
1437

3D Structure Viewer - JSMol  

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Protein Information (From UniProt)

Protein:
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
Other Names:
Atrophin-1-interacting protein 1, Atrophin-1-interacting protein A, Membrane-associated guanylate kinase inverted 2
Primary Accession:
Q86UL8
Other Accessions:
A4D1C1, A7E2C3, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1
Gene :
MAGI2*, synonyms (ACVRINP1, AIP1, KIAA0705)
Organism :
Human
Entry Name :
MAGI2_HUMAN
Length :
1,455
Mass (Da) :
158,754
Last modified :
07-Jan-2006
Version :
v3
Isoforms :
2 
Variants :
14 
Interactions :
1 
Structures :
Experimental 5 | Phyre prediction 10
Function : Show Hide

Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth.

Interactions (From UniProt)

With
Entry
IntAct
Exp
ADRB1
P08588
EBI-311035, EBI-991009
2