Sequence Browser (Q92888-1)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
912

Isoforms (From UniProt)

Isoform
Remark
Ref
Q92888-4
No experimental confirmation available.
VSP_037766 VSP_008125 VSP_057289
Q92888-3
No experimental confirmation available.
VSP_037766
Q92888-1  
Q92888-2
No experimental confirmation available.
VSP_008125
Click on Isoform of interest to be redirected to the corresponding page

Variants (From UniProt)

Type
Variation
Position
splice variant
Missing
76 - 108
sequence variant
M → V
165
mutagenesis site
Y → F
487
sequence conflict
EPA → DPP
257 - 259
sequence conflict
Missing
339
sequence conflict
C → S
549
sequence conflict
S → R
776
sequence conflict
S → R
876
splice variant
M → MASLSTWSSPAEPREM
1
splice variant
VLSLKQLLFPAEEDNGAGPPRDGDGVPGGGPLSPARTQEIQENLLSLEETMKQLEELEEEFCRLRPLLSQLGGNSVPQPGCT → GVGGGILPPETPPVSAWGELCPPAWLHLRFPPRKAFCKKERNGGEDVRDHPHPHSCRSISHPEGLRRGSCGPRLGGAQLGLLAPHEPRPSLPPALCLGDSGLHSGGHHGDPGHLSIACGGHPSTPTPKCLRSVFIP
831 - 912
sequence variant
P → L
375
mutagenesis site
Y → F
738
sequence conflict
VGMP → GGDA
305 - 308
sequence conflict
LGDSSPQ → PGGLIPA
346 - 352
sequence conflict
C → S
752
sequence conflict
L → R
862
sequence conflict
Q → T
883

3D Structure Viewer - JSMol  

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Protein Information (From UniProt)

Protein:
Rho guanine nucleotide exchange factor 1
Other Names:
115 kDa guanine nucleotide exchange factor, Sub1.5
Primary Accession:
Q92888
Other Accessions:
O00513, Q6NX52, Q8N4J4, Q96BF4, Q96F17, Q9BSB1
Gene :
ARHGEF1*
Organism :
Human
Entry Name :
ARHG1_HUMAN
Length :
912
Mass (Da) :
102,435
Last modified :
29-Jan-2003
Version :
v2
Isoforms :
4 
Variants :
17 
Interactions :
3 
Structures :
Experimental 7 | Phyre prediction 3
Function : Show Hide

Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.

Interactions (From UniProt)

With
Entry
IntAct
Exp
TCF4
P15884
EBI-465400, EBI-533224
3
GNA13
Q14344
EBI-465400, EBI-465387
3
Z5115
Q7DB74
EBI-465400, EBI-7864788
7