Sequence Browser (Q92888-2)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
912

Isoforms (From UniProt)

Isoform
Remark
Ref
Q92888-4
No experimental confirmation available.
VSP_037766 VSP_008125 VSP_057289
Q92888-3
No experimental confirmation available.
VSP_037766
Q92888-1
Q92888-2  
No experimental confirmation available.
VSP_008125
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Protein Information (From UniProt)

Protein:
Rho guanine nucleotide exchange factor 1
Other Names:
115 kDa guanine nucleotide exchange factor, Sub1.5
Primary Accession:
Q92888
Other Accessions:
O00513, Q6NX52, Q8N4J4, Q96BF4, Q96F17, Q9BSB1
Gene :
ARHGEF1*
Organism :
Human
Entry Name :
ARHG1_HUMAN
Length :
912
Mass (Da) :
102,435
Last modified :
29-Jan-2003
Version :
v2
Isoforms :
4 
Structures :
Experimental 0 | Phyre prediction 3
Function : Show Hide

Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.