PhyreRisk

Sequence Browser (Q99836-1)

sequence info goes here

Available Structures (Graph-View Mode)

UniProt (Ref Seq)

Displayed Structure

Experimental Tertiary/Complex (PDB:XRay/EM)

Experimental Tertiary/Complex (PDB:NMR)

Modelled Tertiary (Phyre)

If the whole structure is coloured grey in '3D Structure Viewer' panel, please click the icon - on the top left corner of the viewer.
(If nothing changes then 'Sequence ↔ Structure' mapping may be unavailable).

296

To download any of the 3D structure coordinate files, right click on it → select 'Download Structure [xxx]'.

Isoforms (From UniProt)

Isoform

Remark

Ref

Q99836-6

VSP_053765

Q99836-4

No experimental confirmation available.

VSP_043498 VSP_043499 VSP_043500

Q99836-2

No experimental confirmation available.

VSP_038887

Q99836-3

No experimental confirmation available.

VSP_043500

Q99836-5

VSP_053764

Q99836-1

Click on Isoform of interest to be redirected to the corresponding page

Variants (From UniProt)

Type

Variation

Position

splice variant

MAAGGPGAGSAAPVSSTSSLPL → M

1 - 22

splice variant

Missing

110 - 154

splice variant

Missing

111 - 155

splice variant

R → RLARRPRGG

215

sequence variant

V → M

sequence variant

L → P

sequence variant

S → G

136

sequence variant

M → I

178

sequence variant

V → F

204

sequence variant

S → C

206

sequence variant

S → R

209

sequence variant

S → N

230

sequence variant

T → P

281

mutagenesis site

D → A

197

mutagenesis site

K → A

282

sequence conflict

K → T

190

splice variant

E → G

110

splice variant

HMPERFDAFICYCPSDIQFVQEMIRQLEQTNYRLKLCVSDRDVLPGTCVWSIASELIEKRCRRMVVVVSDDYLQSKECDFQTKFALSLSPGAHQKRLIPIKYKAMKKEFPSILRFITVCDYTNPCTKSWFWTRLAKALSLP → AAGWWWLSLMITCRARNVTSRPNLHSASLQVPIRSD

156 - 296

sequence variant

S → Y

sequence variant

Missing

sequence variant

R → C

sequence variant

S → I

136

sequence variant

R → C

196

sequence variant

W → R

205

sequence variant

I → T

207

sequence variant

M → T

219

sequence variant

L → P

252

mutagenesis site

R → A

196

mutagenesis site

R → A

217

mutagenesis site

R → A

288

sequence conflict

VS → WL

223 - 224

3D Structure Viewer - JSMol

3D Structure Information placeholder

To analyse the structural impact of your missense variant:

Select the corresponding experimental/modelled structure from the "Available Structures" Panel.
Right-click on the target structure and download it.
Go to our web server Missense3D to analyse structural impact.

Go to Missense3D

Protein Information (From UniProt)

Protein:

Myeloid differentiation primary response protein MyD88

Primary Accession:

Q99836

Other Accessions:

B4DKH8, B4DKU4, B4DQ60, B4DQ72, J3KPU4, J3KQ87, J3KQJ6, P78397, Q53XS7

Gene :

MYD88*

Organism :

Human

Entry Name :

MYD88_HUMAN

Length :

296

Mass (Da) :

33,233

Last modified :

01-Jan-1997

Version :

Isoforms :

Variants :

Interactions :

Structures :

Experimental 5 | Phyre prediction 3

Function : Show Hide

Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response (PubMed:15361868, PubMed:18292575). Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:15361868, PubMed:24316379, PubMed:19506249). Increases IL-8 transcription (PubMed:9013863). Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity).

Interactions (From UniProt)

With

Entry

IntAct

Exp

Itself

EBI-447677, EBI-447677

BMEI1694

Q8YF33

EBI-447677, EBI-11616155

DOCK8

Q8NF50

EBI-447677, EBI-2548605

IRAK1

P51617

EBI-447677, EBI-358664

IRAK4

Q9NWZ3

EBI-447677, EBI-448378

SIAH1

Q8IUQ4

EBI-447677, EBI-747107

SPOP

O43791

EBI-447677, EBI-743549

TIRAP

P58753

EBI-447677, EBI-528644

TNFRSF13B

O14836

EBI-447677, EBI-519160

USP7

Q93009

EBI-447677, EBI-302474

Q03463

EBI-447677, EBI-8803426

CYTH2

Q99418

EBI-15855480, EBI-448974

FADD

Q13158

EBI-447677, EBI-494804

IRAK4

Q69FE3

EBI-447677, EBI-10249217

SARM1

Q6SZW1

EBI-447677, EBI-11693532

SMAD3

P84022

EBI-447677, EBI-347161

STAP2

Q9UGK3

EBI-447677, EBI-1553984

TLR4

O00206

EBI-447677, EBI-528701

TXN

P10599

EBI-447677, EBI-594644

Method	Phyre
Template	1YGO_A
E-Value	5e-17
Confidence	99.6
Estimated TM	0.882
Coverage	14 - 117
Length	103

Method	NMR
PDB	2JS7
Chain	A
Coverage	146 - 296
Length	150

Method	Phyre
Template	2JS7_A
E-Value	2.1e-18
Confidence	99.7
Estimated TM	0.857
Coverage	147 - 296
Length	149

Method	Phyre
Template	3MOP_A
E-Value	5.4e-21
Confidence	99.8
Estimated TM	0.956
Coverage	20 - 120
Length	100

Method	NMR
PDB	2Z5V
Chain	A
Coverage	148 - 296
Length	148

UniProt	Q99836
Gene	MYD88
Mass (Da)	33233
Organism	Human
Length	296 (1 - 296)

Method	X-ray
PDB	3MOP
Chain	A/B/C/D/E/F
Res (�)	3.4
Coverage	20 - 117
Length	97

Method	X-ray
PDB	4EO7
Chain	A
Res (�)	1.45
Coverage	157 - 296
Length	139

Method	X-ray
PDB	4DOM
Chain	A
Res (�)	1.8
Coverage	157 - 296
Length	139

Sequence Browser (Q99836-1)

Sequence Viewer Preferences

Available Structures (Graph-View Mode)

Isoforms (From UniProt)

Variants (From UniProt)

3D Structure Viewer - JSMol

To analyse the structural impact of your missense variant:

Protein Information (From UniProt)

Interactions (From UniProt)