Sequence Browser (Q99836-6)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
296

Isoforms (From UniProt)

Isoform
Remark
Ref
Q99836-6  
VSP_053765
Q99836-4
No experimental confirmation available.
VSP_043498 VSP_043499 VSP_043500
Q99836-2
No experimental confirmation available.
VSP_038887
Q99836-3
No experimental confirmation available.
VSP_043500
Q99836-5
VSP_053764
Q99836-1
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3D Structure Viewer - JSMol  

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Protein Information (From UniProt)

Protein:
Myeloid differentiation primary response protein MyD88
Primary Accession:
Q99836
Other Accessions:
B4DKH8, B4DKU4, B4DQ60, B4DQ72, J3KPU4, J3KQ87, J3KQJ6, P78397, Q53XS7
Gene :
MYD88*
Organism :
Human
Entry Name :
MYD88_HUMAN
Length :
296
Mass (Da) :
33,233
Last modified :
01-Jan-1997
Version :
v1
Isoforms :
6 
Structures :
Experimental 0 | Phyre prediction 3
Function : Show Hide

Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response (PubMed:15361868, PubMed:18292575). Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:15361868, PubMed:24316379, PubMed:19506249). Increases IL-8 transcription (PubMed:9013863). Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity).