Sequence Browser (Q9BXH1-1)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
193

Isoforms (From UniProt)

Isoform
Remark
Ref
Q96PG8-2
Q9BXH1-1  
Q96PG8-1
Q9BXH1-2
VSP_012238
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Variants (From UniProt)

Type
Variation
Position
splice variant
MARARQEGSSPEPVEGLARDGPRPFPLGRLVPSAVSCGLCEPGLAAAPAAPTLLPAAYLCAPTAPPAVTAALGGSRWPGGPRSRPRGPRPDG → MKFGMGSAQACPCQVPRAASTTWVPCQICG
1 - 92
mutagenesis site
W → A
133

3D Structure Viewer - JSMol  

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Protein Information (From UniProt)

Protein:
Bcl-2-binding component 3
Other Names:
JFY-1, p53 up-regulated modulator of apoptosis
Primary Accession:
Q9BXH1
Other Accessions:
B9EGI3, O00171, Q96PG9
Gene :
BBC3*, synonyms (PUMA)
Organism :
Human
Entry Name :
BBC3_HUMAN
Length :
193
Mass (Da) :
20,532
Last modified :
01-Jan-2001
Version :
v1
Isoforms :
4 
Variants :
2 
Interactions :
5 
Structures :
Experimental 6 | Phyre prediction 0
Function : Show Hide

Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis. Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53. Regulates ER stress-induced neuronal apoptosis.

Interactions (From UniProt)

With
Entry
IntAct
Exp
BCL2
P10415
EBI-519884, EBI-77694
5
BCL2L2
Q92843
EBI-519884, EBI-707714
2
Mcl1
P97287
EBI-519884, EBI-707292
5
BCL2L1
Q07817-1
EBI-519884, EBI-287195
9
MCL1
Q07820
EBI-519884, EBI-1003422
3