Sequence Browser (Q9BZZ2-1)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
1709

Isoforms (From UniProt)

Isoform
Remark
Ref
Q9BZZ2-1  
Q9BZZ2-2
VSP_002571
Q9BZZ2-3
No experimental confirmation available.
VSP_002572
Click on Isoform of interest to be redirected to the corresponding page

Variants (From UniProt)

Type
Variation
Position
splice variant
RRRRVCKQSMGENSVEMAFQKETTQLIDPDAATCETSTCAPPLG → SSLILMQPHVRPQPVPHPWADQWCCLPSGGESGQNL
1666 - 1709
sequence variant
V → M
221
sequence variant
R → H
464
sequence variant
A → V
974
sequence variant
R → W
1487
sequence conflict
A → T
1349
splice variant
ALHRLHQFQQLLWVLGLLVGLLLLLLGLGACYTWRRRRVCKQSMGENSVEMAFQKETTQLIDPDAATCETSTCAPPLG → GEGRGLHLPGHSAQKPSS
1632 - 1709
sequence variant
V → L
141
sequence variant
K → R
239
sequence variant
H → P
919
sequence variant
S → Y
1335
sequence variant
A → P
1519
sequence conflict
A → V
1519

3D Structure Viewer - JSMol  

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Protein Information (From UniProt)

Protein:
Sialoadhesin
Other Names:
Sialic acid-binding Ig-like lectin 1
Primary Accession:
Q9BZZ2
Other Accessions:
Q96DL4, Q9GZS5, Q9H1H6, Q9H1H7, Q9H7L7
Gene :
SIGLEC1*, synonyms (SN)
Organism :
Human
Entry Name :
SN_HUMAN
Length :
1,709
Mass (Da) :
182,624
Last modified :
18-Jan-2001
Version :
v2
Isoforms :
3 
Variants :
13 
Interactions :
0 
Structures :
Experimental 0 | Phyre prediction 8
Function : Show Hide

Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis.

Interactions (From UniProt)

No interactions reported for this protein.