Sequence Browser (Q9BZZ2-3)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
If the whole structure is coloured grey in '3D Structure Viewer' panel, please click the icon - on the top left corner of the viewer.
(If nothing changes then 'Sequence ↔ Structure' mapping may be unavailable).
1
1709

Isoforms (From UniProt)

Isoform
Remark
Ref
Q9BZZ2-1
Q9BZZ2-2
VSP_002571
Q9BZZ2-3  
No experimental confirmation available.
VSP_002572
Click on Isoform of interest to be redirected to the corresponding page

3D Structure Viewer - JSMol  

To analyse the structural impact of your missense variant:

  • Select the corresponding experimental/modelled structure from the "Available Structures" Panel.
  • Right-click on the target structure and download it.
  • Go to our web server Missense3D to analyse structural impact.

    • Go to Missense3D

Protein Information (From UniProt)

Protein:
Sialoadhesin
Other Names:
Sialic acid-binding Ig-like lectin 1
Primary Accession:
Q9BZZ2
Other Accessions:
Q96DL4, Q9GZS5, Q9H1H6, Q9H1H7, Q9H7L7
Gene :
SIGLEC1*, synonyms (SN)
Organism :
Human
Entry Name :
SN_HUMAN
Length :
1,709
Mass (Da) :
182,624
Last modified :
18-Jan-2001
Version :
v2
Isoforms :
3 
Structures :
Experimental 0 | Phyre prediction 7
Function : Show Hide

Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis.