Sequence Browser (Q68DV7-1)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
783

Isoforms (From UniProt)

Isoform
Remark
Ref
Q68DV7-3
No experimental confirmation available.
VSP_037338
Q68DV7-1  
Q68DV7-2
No experimental confirmation available.
VSP_037339
Q68DV7-4
No experimental confirmation available.
VSP_037340
Click on Isoform of interest to be redirected to the corresponding page

Variants (From UniProt)

Type
Variation
Position
splice variant
Missing
85 - 125
sequence variant
I → V
47
sequence variant
R → Q
221
sequence variant
R → H
343
sequence variant
P → R
686
mutagenesis site
H → S
292
mutagenesis site
C → S
298
sequence conflict
M → V
313
sequence conflict
R → G
600
splice variant
Missing
1 - 127
splice variant
SEEELEELCEQAV → EFSEGSGCGRERRLQLNISGQVKSANKGLMEAEKDTAEMTTKILNHRDSVSCWLECRNTPPLPGATPLVGRSQGGPREVLVWLRHQKGTWKAGCDGSCL
771 - 783
sequence variant
R → H
117
sequence variant
P → L
231
sequence variant
L → M
418
mutagenesis site
C → S
290
mutagenesis site
H → S
295
sequence conflict
R → H
225
sequence conflict
E → K
401

3D Structure Viewer - JSMol  

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  • Go to our web server Missense3D to analyse structural impact.

    • Go to Missense3D

Protein Information (From UniProt)

Protein:
E3 ubiquitin-protein ligase RNF43
Other Names:
RING finger protein 43, RING-type E3 ubiquitin transferase RNF43
Primary Accession:
Q68DV7
Other Accessions:
A8K4R2, B7Z443, B7Z5D5, B7Z5J5, Q65ZA4, Q6AI04, Q9NXD0
Gene :
RNF43*
Organism :
Human
Entry Name :
RNF43_HUMAN
Length :
783
Mass (Da) :
85,722
Last modified :
11-Jan-2004
Version :
v1
Isoforms :
4 
Variants :
18 
Interactions :
4 
Structures :
Experimental 1 | Phyre prediction 3
Function : Show Hide

E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.

Interactions (From UniProt)

With
Entry
IntAct
Exp
AKAP8L
Q9ULX6
EBI-1647060, EBI-357530
2
UBE2D2
P62837
EBI-1647060, EBI-347677
2
UBB
P0CG47
EBI-1647060, EBI-413034
2
UBE2D3
P61077
EBI-1647060, EBI-348268
2