To analyse the structural impact of your missense variant:
- Select the corresponding experimental/modelled structure from the "Available Structures" Panel.
- Right-click on the target structure and download it.
- Go to our web server Missense3D to analyse structural impact.
Go to Missense3D
E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator.