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RING-type E3 ubiquitin transferase RNF6
B4DDP0, Q5W0H0, Q9BZP5, Q9UF41
RNF6*, synonyms (SPG2)
Entry Name :
Mass (Da) :
Last modified :
Jan 1, 1999
Experimental 0 | Phyre prediction 3
E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator.