PhyreRisk

Release Information:

Features:

Ability to search PhyreRisk database using UniProt accession, protein name, gene name and disease name
Addition of experimentally derived structures of human proteins from ePDB at EBI
Integration of three molecular viewers (JSMol, 3DMol, NGLViewer)
Integration of SIFTS resource provided by EBI to enable mapping and linking of sequence from UniProt with structure coordinates from PDB
Integration of VEP rest service
Provided ability to input custom variant using genomic coordinates (human build GRCh37 or GRCh38)
Provided ability to add custom variants using protoemic coordinates

Improvements / Issues Resolved:

Updated PhyreRisk database with 20,349 reviewed human proteins from UniProt (Nov 2018)
Resolved bug that prevents JSMol from loading PDB coordinate files containing disulphide bonds (SSBOND)
Added google map and address on contact page
Resolved bug preventing search on the protein page

Known Issues:

3DMol viewer does not load compressed structure coordinate file - experimental structure from PDB are downloaded in a compressed format for performance and efficiency