Sequence Browser (O00219-1)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
If the whole structure is coloured grey in '3D Structure Viewer' panel, please click the icon - on the top left corner of the viewer.
(If nothing changes then 'Sequence ↔ Structure' mapping may be unavailable).
1
553

Isoforms (From UniProt)

Isoform
Remark
Ref
O00219-1  
O00219-2
No experimental confirmation available.
VSP_042022
Click on Isoform of interest to be redirected to the corresponding page

Variants (From UniProt)

Type
Variation
Position
splice variant
ILNKYDSWISFLSSVRYWMAFNVERACQSYFGCVQCISGPLGMYRNSLLQQFLEDWYHQKFLGSKCSFGDDRHLTNRVLSLGYRTKYTARSKCLTETPTKYLRWLNQQTRWSKSYFREWLYNSLWFHKHHLWMTYESVVTGFFPFFLIATVIQLFYRGRIWNILLFLLTVQLVGIIKATYACFLRGNAEMIFMSLYSLLYMSSLLPAKIFAIATINKSGWGTSGRKTIVVNFIGLIPVSIWVAVLLGGLAYTAYCQDLFSETELAFLVSGAILYGCYWVALLMLYLAIIARRCGKKPEQYSLAFAEV → PPGKGMAVEDDQVQAAQVRATEAWSVHQRHVSREQ
247 - 553
sequence conflict
G → E
493
sequence variant
R → H
173

3D Structure Viewer - JSMol  

To analyse the structural impact of your missense variant:

  • Select the corresponding experimental/modelled structure from the "Available Structures" Panel.
  • Right-click on the target structure and download it.
  • Go to our web server Missense3D to analyse structural impact.

    • Go to Missense3D

Protein Information (From UniProt)

Protein:
Hyaluronan synthase 3
Other Names:
Hyaluronate synthase 3, Hyaluronic acid synthase 3
Primary Accession:
O00219
Other Accessions:
A8K5T5, Q8WTZ0, Q9NYP0
Gene :
HAS3*
Organism :
Human
Entry Name :
HYAS3_HUMAN
Length :
553
Mass (Da) :
62,998
Last modified :
23-Jan-2008
Version :
v3
Isoforms :
2 
Variants :
3 
Interactions :
0 
Structures :
Experimental 0 | Phyre prediction 2
Function : Show Hide

Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction (By similarity).

Interactions (From UniProt)

No interactions reported for this protein.