Sequence Browser (Q9GZX7-1)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
198

Isoforms (From UniProt)

Isoform
Remark
Ref
Q9GZX7-1  
Q9GZX7-2
VSP_047803
Click on Isoform of interest to be redirected to the corresponding page

Variants (From UniProt)

Type
Variation
Position
splice variant
Missing
143 - 152
sequence variant
R → W
24
sequence variant
F → L
15
sequence variant
R → C
25
sequence variant
H → Y
56
sequence variant
C → R
87
sequence variant
H → P
130
sequence variant
F → S
151
mutagenesis site
K → A
10
mutagenesis site
R → V
19
mutagenesis site
T → A
27
mutagenesis site
S → A
38
mutagenesis site
ATSF → GGQV
39 - 42
mutagenesis site
R → D
112
sequence conflict
R → H
119
sequence variant
Y → H
31
sequence variant
W → R
80
sequence variant
L → P
106
sequence variant
M → V
139
sequence variant
R → S
174
mutagenesis site
V → S
18
mutagenesis site
W → K
20
mutagenesis site
T → E
27
mutagenesis site
S → D
38
mutagenesis site
R → G
50
mutagenesis site
F → A
193

3D Structure Viewer - JSMol  

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Protein Information (From UniProt)

Protein:
Single-stranded DNA cytosine deaminase
Other Names:
Activation-induced cytidine deaminase, Cytidine aminohydrolase
Primary Accession:
Q9GZX7
Other Accessions:
Q6QJ81, Q8NFC1
Gene :
AICDA*, synonyms (AID)
Organism :
Human
Entry Name :
AICDA_HUMAN
Length :
198
Mass (Da) :
23,954
Last modified :
01-Jan-2001
Version :
v1
Isoforms :
2 
Variants :
26 
Interactions :
12 
Structures :
Experimental 5 | Phyre prediction 2
Function : Show Hide

Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses (PubMed:18722174, PubMed:21385873, PubMed:21518874, PubMed:27716525). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (PubMed:21496894).

Interactions (From UniProt)

With
Entry
IntAct
Exp
Itself
EBI-3834328, EBI-3834328
2
C
Q784Z8
EBI-3834328, EBI-11666471
2
DNAJA2
O60884
EBI-3834328, EBI-352957
3
HSPA8
P11142
EBI-3834328, EBI-351896
2
KPNA3
O00505
EBI-3834328, EBI-358297
2
PRKACA
P17612
EBI-3834328, EBI-476586
3
TDG
Q13569
EBI-3834328, EBI-348333
5
DNAJA1
P31689
EBI-3834328, EBI-347834
6
GADD45A
P24522
EBI-3834328, EBI-448167
5
KPNA1
P52294
EBI-3834328, EBI-358383
2
KPNA5
O15131
EBI-3834328, EBI-540602
2
PRKAR1A
P10644
EBI-3834328, EBI-476431
5