Sequence Browser (P08235-1)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
984

Isoforms (From UniProt)

Isoform
Remark
Ref
P08235-1  
P08235-2
Lacks steroid-binding activity and acts as ligand-independent transactivator.
VSP_007358 VSP_007359
P08235-3
VSP_007357
P08235-4
VSP_007360
Click on Isoform of interest to be redirected to the corresponding page

Variants (From UniProt)

Type
Variation
Position
splice variant
G → GKCSW
633
splice variant
ARKSKKLGKLKGIHEEQPQQQQPPPPPPPPQSPEE → ERRCISLPCMNYARGCTKSAFSSFDCSSPLKNTPS
672 - 706
sequence variant
H → Q
7
sequence variant
A → V
241
sequence variant
R → Q
537
sequence variant
G → R
633
sequence variant
R → S
659
sequence variant
L → P
769
sequence variant
Q → R
776
sequence variant
S → L
810
sequence variant
S → L
818
sequence variant
L → P
924
sequence variant
L → P
979
splice variant
Missing
672 - 788
splice variant
Missing
707 - 984
sequence variant
I → V
180
sequence variant
N → T
444
sequence variant
N → S
554
sequence variant
C → S
645
sequence variant
P → S
759
sequence variant
N → K
770
sequence variant
S → P
805
sequence variant
S → R
815
sequence variant
F → Y
826
sequence variant
E → G
972
mutagenesis site
S → N
767
mutagenesis site
N → A,D,H,Q,S,T
770
mutagenesis site
K → E
782
mutagenesis site
E → R
796
mutagenesis site
S → M
810
mutagenesis site
C → S
849
mutagenesis site
T → A
945
mutagenesis site
K → A
953
mutagenesis site
F → A
956
sequence conflict
F → I
946
mutagenesis site
S → Q
767
mutagenesis site
Q → A
776
mutagenesis site
K → E
785
mutagenesis site
C → S
808
mutagenesis site
R → A
817
mutagenesis site
C → S
942
mutagenesis site
L → A
952
mutagenesis site
V → A
954
mutagenesis site
P → A
957

3D Structure Viewer - JSMol  

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Protein Information (From UniProt)

Protein:
Mineralocorticoid receptor
Other Names:
Nuclear receptor subfamily 3 group C member 2
Primary Accession:
P08235
Other Accessions:
B0ZBF5, B0ZBF7, Q2NKL1, Q96KQ8, Q96KQ9
Gene :
NR3C2*, synonyms (MCR, MLR)
Organism :
Human
Entry Name :
MCR_HUMAN
Length :
984
Mass (Da) :
107,067
Last modified :
01-Jan-1988
Version :
v1
Isoforms :
4 
Variants :
44 
Interactions :
0 
Structures :
Experimental 25 | Phyre prediction 3
Function : Show Hide

Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.

Interactions (From UniProt)

No interactions reported for this protein.