To analyse the structural impact of your missense variant:
- Select the corresponding experimental/modelled structure from the "Available Structures" Panel.
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- Go to our web server Missense3D to analyse structural impact.
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Protein:
Other Names:
Nuclear receptor subfamily 3 group C member 2
Primary Accession:
Other Accessions:
B0ZBF5, B0ZBF7, Q2NKL1, Q96KQ8, Q96KQ9
Gene
:
NR3C2*, synonyms (MCR, MLR)
Organism
:
Human
Entry
Name :
Length
:
984
Mass (Da)
:
107,067
Last
modified :
01-Jan-1988
Version
:
v1
Isoforms
:
4
Structures
:
Experimental 0 | Phyre prediction 2
Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.