Sequence Browser (P08235-4)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
984

Isoforms (From UniProt)

Isoform
Remark
Ref
P08235-1
P08235-2
Lacks steroid-binding activity and acts as ligand-independent transactivator.
VSP_007358 VSP_007359
P08235-3
VSP_007357
P08235-4  
VSP_007360
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Protein Information (From UniProt)

Protein:
Mineralocorticoid receptor
Other Names:
Nuclear receptor subfamily 3 group C member 2
Primary Accession:
P08235
Other Accessions:
B0ZBF5, B0ZBF7, Q2NKL1, Q96KQ8, Q96KQ9
Gene :
NR3C2*, synonyms (MCR, MLR)
Organism :
Human
Entry Name :
MCR_HUMAN
Length :
984
Mass (Da) :
107,067
Last modified :
01-Jan-1988
Version :
v1
Isoforms :
4 
Structures :
Experimental 0 | Phyre prediction 3
Function : Show Hide

Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.