Sequence Browser (Q13535-1)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
2644

Isoforms (From UniProt)

Isoform
Remark
Ref
Q13535-1  
Q13535-3
No experimental confirmation available.
VSP_036907 VSP_036908
Q13535-2
VSP_013305 VSP_013304
Click on Isoform of interest to be redirected to the corresponding page

Variants (From UniProt)

Type
Variation
Position
splice variant
E → D
450
splice variant
AKTHVLDIEQRLQGVIKTRNRVT → VSRRYSLIWAVVLISTNELDMQL
2588 - 2610
sequence variant
T → A
64
sequence variant
M → T
211
sequence variant
V → I
316
sequence variant
Y → H
1087
sequence variant
A → P
1488
sequence variant
S → N
1607
sequence variant
A → G
2002
sequence variant
Y → D
2132
sequence variant
S → I
2233
sequence variant
P → A
2434
sequence variant
E → Q
2537
mutagenesis site
D → A
2475
sequence conflict
A → R
92
splice variant
Missing
451 - 514
splice variant
Missing
2611 - 2644
sequence variant
H → Y
90
sequence variant
K → N
297
sequence variant
V → M
959
sequence variant
S → G
1213
sequence variant
I → V
1526
sequence variant
N → S
1612
sequence variant
G → A
2120
sequence variant
Q → R
2144
sequence variant
R → Q
2425
sequence variant
E → K
2438
mutagenesis site
K → R
2327
mutagenesis site
D → E
2494

3D Structure Viewer - JSMol  

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Protein Information (From UniProt)

Protein:
Serine/threonine-protein kinase ATR
Other Names:
Ataxia telangiectasia and Rad3-related protein, FRAP-related protein 1
Primary Accession:
Q13535
Other Accessions:
Q59HB2, Q7KYL3, Q93051, Q9BXK4
Gene :
ATR*, synonyms (FRP1)
Organism :
Human
Entry Name :
ATR_HUMAN
Length :
2,644
Mass (Da) :
301,367
Last modified :
05-Jan-2004
Version :
v3
Isoforms :
3 
Variants :
29 
Interactions :
6 
Structures :
Experimental 1 | Phyre prediction 0
Function : Show Hide

Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.

Interactions (From UniProt)

With
Entry
IntAct
Exp
ATRIP
Q8WXE1
EBI-968983, EBI-747353
3
CDK9
P50750
EBI-968983, EBI-1383449
3
IKBKG
Q9Y6K9
EBI-968983, EBI-81279
2
CDC5L
Q99459
EBI-968983, EBI-374880
3
CINP
Q9BW66
EBI-968983, EBI-739784
5
TTI1
O43156
EBI-968983, EBI-1055680
2